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COVID-19 Antibody Testing

COVID-19 Antibody Testing

COVID-19 Antibody Testing – whether you have had the virus, and how strong your immunity is.

Immunity testing: whether the individual has had COVID-19, or has been vaccinated, and how strong the immunity is.

The Circular1 Health antibody test proves whether detectable levels of antibody to SARS-CoV-2 are present, this is the virus that causes COVID-19.  The test also shows how high the antibody levels are. 

If the individual is positive (they have had the virus or have been vaccinated), it will determine whether the response is low, medium, strong or very strong.  If positive the test will establish a baseline level for the antibody response which, in subsequent tests, will show if the antibody level is changing over time.

This test measures the levels of two antibody types against SARS-CoV-2: IgM – the ‘early response’ antibody and IgG – which is present in the blood after a few weeks have elapsed.  Some other tests only detect IgG antibodies; the Circular1 Health test will detect around 20% of people who have IgM antibodies, but who do not have detectable IgG antibodies.

The test is a laboratory-based enzyme-linked immunosorbent assay (ELISA), a commonly used biochemical test that can be used to detect antibodies to many infectious diseases.  It works by contacting a small amount of an individual’s blood from a finger-prick or a venous blood draw with a plastic surface on which a synthetic protein (the ‘antigen’) from the virus is immobilised.  If antibodies to SARS-CoV-2 or the vaccine are present in an individual’s blood they will recognise and bind to this immobilised viral protein and can then be detected subsequently.

The Circular1 Health antibody test sensitivity in community COVID-19 cases is >86%, competitor tests from two other companies have been reported as 68% and 69% sensitive. In hospitalised cases the sensitivity of the Circular1 Health antibody test is 100%.

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